Reviews
Assessments on biotechnology and related fields by Dr. Haifeng Chen, informed by 30 years of gene therapy expertise.
AAV Capsid Engineering: From Random Diversification to Precision Receptor-Guided Targeting
From empirical capsid diversification and directed evolution to receptor-first precision engineering and targeted gene delivery
Published November 10, 2026
Keywords: AAV capsid engineering, adeno-associated virus, directed evolution, peptide display, DNA family shuffling, structure-guided engineering, computational capsid design, receptor-mediated targeting, Precision AAV Capsid Engineering (PACE), CD3scFv-AAV, in vivo CAR-T therapy
In Vivo CAR-T for Autoimmune Diseases: The Potential of T-Cell-Targeted AAV Gene Delivery
Lessons from ex vivo CAR-T, emerging in vivo clinical data, and the potential therapeutic window for AAV-mediated T-cell engineering
Published September 3, 2026
Keywords: in vivo CAR-T, autoimmune disease, CAR-T cell therapy, CD19 CAR-T, immune reset, B-cell depletion, AAV, adeno-associated virus, T-cell-targeted AAV, CD3-targeted AAV, CD3scFv-AAV, AAV capsid engineering, mRNA/LNP, lentiviral vector, lymphodepletion, cytokine release syndrome, IEC-HS