In Vivo CAR-T for Autoimmune Diseases: The Potential of T-Cell-Targeted AAV Gene Delivery
Lessons from ex vivo CAR-T, emerging in vivo clinical data, and the potential therapeutic window for AAV-mediated T-cell engineering
Haifeng Chen
Published September 3, 2026
Tags: reviews
Keywords: in vivo CAR-T, autoimmune disease, CAR-T cell therapy, CD19 CAR-T, immune reset, B-cell depletion, AAV, adeno-associated virus, T-cell-targeted AAV, CD3-targeted AAV, CD3scFv-AAV, AAV capsid engineering, mRNA/LNP, lentiviral vector, lymphodepletion, cytokine release syndrome, IEC-HS